The challenge of recurrent follicular lymphoma.

Lancet Oncol. 2011 Aug;12(8):714-6. Epub 2011 Jul 1.

Tomás JF.

Follicular lymphoma is the second most common type of lymphoma in high-income countries, representing nearly 20% of all non-Hodgkin lymphomas. The pathogenesis of follicular lymphoma remains elusive and evidence exists that t(14;18)(q32;q21), the most common genetic alteration in follicular-lymphoma cells, which results in an overproduction of the antiapoptotic BCL-2 protein, is not sufficient to cause the disease.